D72.0

Applicable To

• Alder granulation) granulocyte) anomaly

• Alder syndrome

• Hereditary leukocytic hypersegmentation

• Hereditary leukocytic hyposegmentation

• Hereditary leukomelanopathy

• May-Hegglin granulation) granulocyte) anomaly

• May-Hegglin syndrome

• Pelger-Huët granulation) granulocyte) anomaly

• Pelger-Huët syndrome

Approximate Synonyms

• Alder syndrome

• Alders syndrome

• Chediak higashi syndrome

• Chédiak-higashi syndrome

• Genetic anomaly of leukocyte

• Hereditary giant neutrophilia

• Hereditary hypersegmentation

• Hypersegmentation

• Hypersegmentation, hereditary

• Leukocyte adhesion deficiency – type 1

• Leukocyte adhesion deficiency – type 2

• Leukocyte adhesion deficiency type 1

• Leukocyte adhesion deficiency type 2

• Leukocyte disorder, genetic

• May hegglin anomaly

• Pelger-huet anomaly

• Pelger-huët anomaly

• Pelger-huît anomaly

Clinical Information

• A form of phagocyte bactericidal dysfunction characterized by unusual oculocutaneous albinism, high incidence of lymphoreticular neoplasms, and recurrent pyogenic infections. In many cell types, abnormal lysosomes are present leading to defective pigment distribution and abnormal neutrophil functions. The disease is transmitted by autosomal recessive inheritance and a similar disorder occurs in the beige mouse, the aleutian mink, and albino hereford cattle.

• A rare autosomal recessive immunodeficiency disorder characterized by abnormal intracellular protein transport. Chediak-higashi syndrome chs) is characterized by immune deficiency; partial oculocutaneous albinism; a bleeding disorder due to deficient platelet dense bodies; neutropenia; neutrophils with impaired chemotaxis and bactericidal activity; recurrent infection; and abnormal natural killer nk) cell function. Chs may be associated with hepatosplenomegaly, lymphadenopathy, anemia, thrombocytopenia, roentgenologic changes in bones, lungs and heart, and skin and psychomotor abnormalities; it is often fatal in childhood as a result of infection or an accelerated lymphoma-like phase. Chs occurs in mink, cattle, and mice, as well as man.

• Form of phagocyte bactericidal dysfunction characterized by unusual oculocutaneous albinism, high incidence of lymphoreticular neoplasms, and recurrent pyogenic infections; in many cell types, abnormal lysosomes are present leading to defective pigment distribution and abnormal neutrophil functions; transmitted by autosomal recessive inheritance and a similar disorder occurs in the beige mouse, the aleutian mink, and albino hereford cattle.

Details

• D72.0 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.

• The 2023 edition of ICD-10-CM D72.0 became effective on October 1, 2022.

• This is the American ICD-10-CM version of D72.0 – other international versions of ICD-10 D72.0 may differ.