A81.2

Applicable To

• Multifocal leukoencephalopathy NOS

Clinical Information

• A progressive demyelination within the central nervous system associated with reactivation of a latent jc virus infection.

• An opportunistic viral infection of the central nervous system associated with conditions that impair cell-mediated immunity e.g., acquired immunodeficiency syndrome and other immunologic deficiency syndromes; hematologic neoplasms; immunosuppression; and collagen diseases). The causative organism is jc polyomavirus jc virus) which primarily affects oligodendrocytes, resulting in multiple areas of demyelination. Clinical manifestations include dementia; ataxia; visual disturbances; and other focal neurologic deficits, generally progressing to a vegetative state within 6 months. from Joynt, Clinical Neurology, 1996, ch26, pp36-7)

• Demyelination in various part of the central nervous system, usually secondary to neoplastic disease; jc virus has been recovered from brain tissue.

Details

• A81.2 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.

• The 2023 edition of ICD-10-CM A81.2 became effective on October 1, 2022.

• This is the American ICD-10-CM version of A81.2 – other international versions of ICD-10 A81.2 may differ.