A81.82

Applicable To

• GSS syndrome

Approximate Synonyms

• Gerstmann-straussler-scheinker syndrome

Clinical Information

• A very rare and fatal disorder of spongiform encephalopathy usually caused by mutations of the prion protein prnp) gene. It is characterized by the accumulation of amyloid in the brain. Signs and symptoms include lack of motor coordination, unsteady gait, and difficulty walking. As the disease progresses, patients develop speech difficulties and dementia.

• An autosomal dominant familial prion disease with a wide spectrum of clinical presentations including ataxia, spastic paraparesis, extrapyramidal signs, and dementia. Clinical onset is in the third to sixth decade of life and the mean duration of illness prior to death is five years. Several kindreds with variable clinical and pathologic features have been described. Pathologic features include cerebral prion protein amyloidosis, and spongiform or neurofibrillary degeneration. from brain pathol 1998 jul;8 3):499-513; brain pathol 1995 jan;5 1):61-75)

Details

• A81.82 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.

• Short description: Gerstmann-Straussler-Scheinker syndrome

• The 2023 edition of ICD-10-CM A81.82 became effective on October 1, 2022.

• This is the American ICD-10-CM version of A81.82 – other international versions of ICD-10 A81.82 may differ.