C25.4

Applicable To

• Malignant neoplasm of islets of Langerhans

Approximate Synonyms

• Cancer of the islets of langerhans

• Malignant glucagonoma

• Primary malignant neoplasm of islets of langerhans

Clinical Information

• A malignant endocrine neoplasm arising from islets of langerhans of the pancreas.

• A primary malignant neoplasm of the pancreatic islet cells. Usually it involves the non-insulin-producing cell types, the pancreatic alpha cells and the pancreatic delta cells somatostatin-secreting cells) in glucagonoma and somatostatinoma, respectively.

• An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the pancreas. The mitotic count is more than 20 per 10 hpf. According to the size of the malignant cells, the prominence of the nucleoli, and the amount of cytoplasm, it is classified either as small or large cell neuroendocrine carcinoma.

• Cancer arising from cells in the islets of langerhans, which are found in the pancreas.

Details

• C25.4 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.

• The 2023 edition of ICD-10-CM C25.4 became effective on October 1, 2022.

• This is the American ICD-10-CM version of C25.4 – other international versions of ICD-10 C25.4 may differ.