C84.4

Applicable To

• Lennert’s lymphoma

• Lymphoepithelioid lymphoma

• Mature T-cell lymphoma, not elsewhere classified

Clinical Information

• A group of malignant lymphomas thought to derive from peripheral t-lymphocytes in lymph nodes and other nonlymphoid sites. They include a broad spectrum of lymphocyte morphology, but in all instances express t-cell markers admixed with epithelioid histiocytes, plasma cells, and eosinophils. Although markedly similar to large-cell immunoblastic lymphoma lymphoma, large-cell, immunoblastic), this group’s unique features warrant separate treatment.

• A variant of peripheral t-cell lymphoma, not otherwise specified. It is characterized by the presence of neoplastic small lymphocytes infiltrating the lymph nodes in a diffuse and less frequently interfollicular pattern. There is an associated proliferation of epithelioid histiocytes forming confluent clusters.

• Aggressive nodal or extranodal mature peripheral) t-cell lymphomas that do not belong to the better defined entities of the remainder of mature t-cell lymphomas. This category includes the following variants: lymphoepithelioid cell variant lennert’s lymphoma), follicular variant, and t-zone variant.

• One of a group of aggressive fast-growing) non-hodgkin lymphomas that begin in mature t lymphocytes t cells that have matured in the thymus gland and gone to other lymphatic sites in the body, including lymph nodes, bone marrow, and spleen.)

• One of a group of aggressive fast-growing) non-hodgkin lymphomas that begins in mature t lymphocytes t cells that have matured in the thymus gland and goes to other lymphatic sites in the body, including lymph nodes, bone marrow, and spleen.)

• This type of lymphoma is not frequently seen in the western hemisphere. Clinically, with the exception of anaplastic large cell lymphoma, mature t- and nk-cell lymphomas are among the most aggressive of all hematopoietic neoplasms. Representative disease entities include mycosis fungoides, angioimmunoblastic t-cell lymphoma, hepatosplenic t-cell lymphoma, and anaplastic large cell lymphoma.

Details

• C84.4 should not be used for reimbursement purposes as there are multiple codes below it that contain a greater level of detail.

• ICD-10-CM C84.4 is a revised 2023 ICD-10-CM code that became effective on October 1, 2022.

• This is the American ICD-10-CM version of C84.4 – other international versions of ICD-10 C84.4 may differ.