C84.6

Applicable To

• Anaplastic large cell lymphoma, CD30-positive

Clinical Information

• A peripheral mature) t-cell lymphoma, consisting of usually large anaplastic, cd30 positive cells. The majority of cases are positive for the anaplastic large cell lymphoma alk) protein. The most frequently seen genetic alteration is a t 2;5) translocation. Majority of patients present with advanced disease. The most important prognostic indicator is alk positivity, which has been associated with a favorable prognosis. who, 2001)

• A systemic, large-cell, non-hodgkin, malignant lymphoma characterized by cells with pleomorphic appearance and expressing the cd30 antigen. These so-called “hallmark” cells have lobulated and indented nuclei. This lymphoma is often mistaken for metastatic carcinoma and malignant histiocytosis.

• A t-cell peripheral lymphoma composed of usually large, pleomorphic, cd30 positive t-lymphocytes with abundant cytoplasm characterized by the presence of a translocation involving the alk gene and expression of alk fusion protein. Most patients present with peripheral and/or abdominal lymphadenopathy, and often have advanced disease and extranodal involvement.

• An aggressive fast-growing) type of non-hodgkin lymphoma that is usually of the t-cell type. The cancer cells express a marker called cd30 or ki-1 on the surface, and may appear in the lymph nodes, skin, bones, soft tissues, lungs, or liver.

Details

• C84.6 should not be used for reimbursement purposes as there are multiple codes below it that contain a greater level of detail.

• The 2023 edition of ICD-10-CM C84.6 became effective on October 1, 2022.

• This is the American ICD-10-CM version of C84.6 – other international versions of ICD-10 C84.6 may differ.