C88.0

Applicable To

• Lymphoplasmacytic lymphoma with IgM-production

• Macroglobulinemia idiopathic) primary)

Approximate Synonyms

• Macroglobulinemia

• Waldenstrˆm macroglobulinemia

• Waldenstroms macroglobulinemia

Clinical Information

• mak-ro-glob-u-li-ne-me-uh) a condition in which the blood contains high levels of large proteins and is too thick to flow through small blood vessels. One type is waldenstrom’s macroglobulinemia, which is a type of cancer.

• A clonal neoplasm of small b-lymphocytes, lymphoplasmacytoid cells, and plasma cells involving the bone marrow, lymph nodes, and the spleen. The majority of patients have a serum igm paraprotein. Lymphoplasmacytic lymphoma/waldenstrom’s macroglobulinemia is a relatively rare condition accounting for approximately 2% of hematologic malignancies. Symptoms include: weakness and fatigue, hemorrhagic manifestations, weight loss, and visual disturbances. Physical findings include: hepatomegaly, splenomegaly, fundic changes, adenopathy, neurologic abnormalities, and purpura. The most common laboratory finding is anemia. Treatment includes: chemotherapy alkylating agents, nucleoside analogues) radiotherapy, and plasmapheresis. Bone marrow transplant is being investigated. Asymptomatic patients may be monitored without treatment until complications occur.

• A lymphoproliferative disorder characterized by pleomorphic b-lymphocytes including plasma cells, with increased levels of monoclonal serum immunoglobulin m. There is lymphoplasmacytic cells infiltration into bone marrow and often other tissues, also known as lymphoplasmacytic lymphoma. Clinical features include anemia; hemorrhages; and hyperviscosity.

• A rare cancer of the lymph cells that causes the body to produce abnormal levels of plasma cells plasmacytosis) and lymphocytes lymphocytosis) in the bone marrow. Waldenstrom’s macroglobulinemia may also cause a decrease in the number of red blood cells anemia) and enlargement of the liver hepatomegaly), spleen splenomegaly), or glands adenopathy).

• An indolent slow-growing) type of non-hodgkin lymphoma marked by abnormal levels of igm antibodies in the blood and an enlarged liver, spleen, or lymph nodes.

• Lymphoplasmacytic lymphoma associated with bone marrow involvement and igm monoclonal gammopathy.

• Plasma cell dyscrasia resembling leukemia, with cells of lymphocytic, plasmacytic, or intermediate morphology, that secrete an igm monoclonal component.

Details

• C88.0 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.

• Short description: Waldenstrom macroglobulinemia

• The 2023 edition of ICD-10-CM C88.0 became effective on October 1, 2022.

• This is the American ICD-10-CM version of C88.0 – other international versions of ICD-10 C88.0 may differ.