C91.1

Applicable To

• Lymphoplasmacytic leukemia

• Richter syndrome

Clinical Information

• A chronic leukemia characterized by abnormal b-lymphocytes and often generalized lymphadenopathy. In patients presenting predominately with blood and bone marrow involvement it is called chronic lymphocytic leukemia cll); in those predominately with enlarged lymph nodes it is called small lymphocytic lymphoma. These terms represent spectrums of the same disease.

• A rare condition in which chronic lymphocytic leukemia cll) changes into a fast-growing type of lymphoma. Symptoms of richter syndrome include fever, loss of weight and muscle mass, and other health problems.

• An indolent slow-growing) cancer in which too many immature lymphocytes white blood cells) are found mostly in the blood and bone marrow. Sometimes, in later stages of the disease, cancer cells are found in the lymph nodes and the disease is called small lymphocytic lymphoma.

• Chronic leukemia characterized by morphologically mature but immunologically less mature lymphocytes; manifested by an abnormal accumulation of these cells in blood, bone marrow, and lymphatic tissue.

• leukemia is cancer of the white blood cells. White blood cells help your body fight infection. Your blood cells form in your bone marrow. In leukemia, the bone marrow produces abnormal white blood cells. These cells crowd out the healthy blood cells, making it hard for blood to do its work. In chronic lymphocytic leukemia cll), there are too many lymphocytes, a type of white blood cell.cll is the second most common type of leukemia in adults. It often occurs during or after middle age, and is rare in children.usually cll does not cause any symptoms. If you have symptoms, they may include

• The most common type of chronic lymphoid leukemia. It comprises 90% of chronic lymphoid leukemias in the United States. Morphologically, the neoplastic cells are small, round b-lymphocytes. This type of leukemia is not considered to be curable with available therapy. who, 2001)

• Transformation of chronic lymphocytic leukemia into aggressive non-hodgkin’s lymphoma, usually diffuse large b-cell lymphoma immunoblastic or centroblastic variant). Occasional cases of transformation to hodgkin’s lymphoma have also been described, particularly in patients treated with purine nucleotide analogues. Molecular genetic studies suggest that in approximately half of the cases, the lymphoma is clonally related to the underlying chronic lymphocytic leukemia, whereas in the remaining cases the lymphoma probably represents a secondary, unrelated neoplasm.

Details

• C91.1 should not be used for reimbursement purposes as there are multiple codes below it that contain a greater level of detail.

• The 2023 edition of ICD-10-CM C91.1 became effective on October 1, 2022.

• This is the American ICD-10-CM version of C91.1 – other international versions of ICD-10 C91.1 may differ.