C92.1

Applicable To

• Chronic myelogenous leukemia, Philadelphia chromosome Ph1) positive

• Chronic myelogenous leukemia, t 9;22)

• Chronic myelogenous leukemia with crisis of blast cells

Clinical Information

• A chronic myeloproliferative neoplasm characterized by the expression of the bcr-abl1 fusion gene. It presents with neutrophilic leukocytosis. It can appear at any age, but it mostly affects middle aged and older individuals. Patients usually present with fatigue, weight loss, anemia, night sweats, and splenomegaly. If untreated, it follows a biphasic or triphasic natural course; an initial indolent chronic phase which is followed by an accelerated phase, a blast phase, or both. Allogeneic stem cell transplantation and imatinib therapy delay disease progression and prolong overall survival.

• A slowly progressing disease in which too many white blood cells are made in the bone marrow.

• Chronic leukemia in which myeloid progenitor cells predominate; the hallmark of cml, the philadelphia chromosome, is a reciprocal translocation between chromosomes 9 and 22 which activates the proto- oncogene c-abl.

• Clonal hematopoetic disorder caused by an acquired genetic defect in pluripotent stem cells. It starts in myeloid cells of the bone marrow, invades the blood and then other organs. The condition progresses from a stable, more indolent, chronic phase leukemia, myeloid, chronic phase) lasting up to 7 years, to an advanced phase composed of an accelerated phase leukemia, myeloid, accelerated phase) and blast crisis.

• leukemia is cancer of the white blood cells. White blood cells help your body fight infection. Your blood cells form in your bone marrow. In leukemia, the bone marrow produces abnormal white blood cells. These cells crowd out the healthy blood cells, making it hard for blood to do its work. In chronic myeloid leukemia cml), there are too many granulocytes, a type of white blood cell.most people with cml have a gene mutation change) called the philadelphia chromosome.sometimes cml does not cause any symptoms. If you have symptoms, they may include:

Details

• C92.1 should not be used for reimbursement purposes as there are multiple codes below it that contain a greater level of detail.

• The 2023 edition of ICD-10-CM C92.1 became effective on October 1, 2022.

• This is the American ICD-10-CM version of C92.1 – other international versions of ICD-10 C92.1 may differ.