C94.8

Applicable To

• Aggressive NK-cell leukemia

• Acute basophilic leukemia

Clinical Information

• A rare acute myeloid leukemia in which the primary differentiation is to basophils. It is characterized by an extreme increase of immature basophilic granulated cells in the bone marrow and blood. Mature basophils are usually sparse.

• A rare, highly aggressive, epstein-barr virus-associated leukemia, also known as aggressive nk-cell leukemia/lymphoma; it may represent the leukemic counterpart of nasal type extranodal nk/t-cell lymphomas. It affects primarily teenagers and young adults. It is characterized by the systemic proliferation of nk cells in the peripheral blood, bone marrow, liver, and spleen.

• An acute myeloid leukemia in which the immature cells differentiate towards basophils. This is a rare leukemia. The observed cases have been associated with a poor prognosis. The term basophilic leukemia is used as a synonym for acute basophilic leukemia. Chronic basophilic leukemia is an inappropriate term vaguely connected to the term mast cell leukemia. who, 2001)

Details

• C94.8 should not be used for reimbursement purposes as there are multiple codes below it that contain a greater level of detail.

• The 2023 edition of ICD-10-CM C94.8 became effective on October 1, 2022.

• This is the American ICD-10-CM version of C94.8 – other international versions of ICD-10 C94.8 may differ.