C96.5

Applicable To

• Hand-Schüller-Christian disease

• Histiocytosis X, multifocal

Approximate Synonyms

• Hand-sch¸ller-christian disease

• Hand-schüller-christian disease

• Langerhans cell histiocytosis, multifoc unisystem

Clinical Information

• A group of disorders resulting from the abnormal proliferation of and tissue infiltration by langerhans cells which can be detected by their characteristic birbeck granules x bodies), or by monoclonal antibody staining for their surface cd1 antigens. Langerhans-cell granulomatosis can involve a single organ, or can be a systemic disorder.

• A group of rare disorders in which too many langerhans cells a type of white blood cell) grow in certain tissues and organs including the bones, skin, and lungs, and damage them. Langerhans cell histiocytosis may also affect the pituitary gland which makes hormones that control other glands and many body functions, especially growth). Langerhans cell histiocytosis is most common in children and young adults.

• A multifocal, unisystem form of langerhans-cell histiocytosis. There is involvement of multiple sites in one organ system, most frequently the bone. Patients are usually young children presenting with multiple destructive bone lesions.

• A neoplastic proliferation of langerhans cells which contain birbeck granules by ultrastructural examination. Three major overlapping syndromes are recognized: eosinophilic granuloma, letterer-siwe disease, and hand-schuller-christian disease. The clinical course is generally related to the number of organs affected at presentation. who, 2001)

• Group of disorders of histiocyte proliferation which includes letterer-siwe disease; hand-schueller-christian syndrome; and eosinophilic granuloma; langerhans cells are components of the lesions.

Details

• C96.5 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.

• The 2023 edition of ICD-10-CM C96.5 became effective on October 1, 2022.

• This is the American ICD-10-CM version of C96.5 – other international versions of ICD-10 C96.5 may differ.