D59.5

Approximate Synonyms

• Paroxsymal nocturia hemoglobinuria

• Paroxysmal nocturnal hemoglobinuria

Clinical Information

• A rare acquired hematologic disorder characterized by hemolytic anemia, dark-colored urine due to the release of hemoglobin in the blood, and thrombosis. The episodes of hemolysis tend to occur at night. It is caused by a somatic mutation in the glycosylphosphatidylinositol biosynthesis gene.

• A rare disorder in which red blood cells are easily destroyed by certain immune system proteins. Symptoms include blood clots, and red or brownish urine in the morning. Aplastic anemia decreased production of blood cells) may lead to pnh, and people with pnh are at increased risk of acute myelogenous leukemia.

• Disorder characterized by intravascular hemolysis and hemoglobinuria; some cases occur on exposure to cold and are due to the presence of an autohemolysin in the serum; other cases are more marked during or immediately after sleep and are considered to be due to an acquired intracorpuscular defect.

Details

• D59.5 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.

• The 2023 edition of ICD-10-CM D59.5 became effective on October 1, 2022.

• This is the American ICD-10-CM version of D59.5 – other international versions of ICD-10 D59.5 may differ.