D75.81

ICD-10-CM Coding Rules

• D75.81

Applicable To

• Myelofibrosis NOS

• Secondary myelofibrosis NOS

Approximate Synonyms

• Secondary myelofibrosis

Clinical Information

• A chronic myeloproliferative neoplasm characterized by bone marrow fibrosis, proliferation of atypical megakaryocytes and granulocytes in the bone marrow, anemia, splenomegaly, and extramedullary hematopoiesis. The cause is unknown. The median survival time is 3-5 years from diagnosis. who, 2001)

• A de novo myeloproliferation arising from an abnormal stem cell. It is characterized by the replacement of bone marrow by fibrous tissue, a process that is mediated by cytokines arising from the abnormal clone.

• A disorder in which the bone marrow is replaced by fibrous tissue.

• A partial or complete replacement of the bone marrow stroma by fibrous tissue. It can be a primary bone marrow lesion as part of the chronic myeloproliferative disorders chronic idiopathic myelofibrosis), a manifestation of acute myeloid leukemia acute panmyelosis with myelofibrosis), or a secondary phenomenon due to bone marrow involvement by a metastatic tumor e.g., metastatic breast carcinoma).

• A progressive, chronic disease in which the bone marrow is replaced by fibrous tissue and blood is made in organs such as the liver and the spleen, instead of in the bone marrow. This disease is marked by an enlarged spleen and progressive anemia.

• Replacement of the bone marrow by fibrous tissue, occurring in association with a myeloproliferative disorder or secondary to another unrelated condition.

Details

• D75.81 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.

• The 2023 edition of ICD-10-CM D75.81 became effective on October 1, 2022.

• This is the American ICD-10-CM version of D75.81 – other international versions of ICD-10 D75.81 may differ.