D89.81

Clinical Information

• A disease caused when cells from a donated stem cell graft attack the normal tissue of the transplant patient. Symptoms include jaundice, skin rash or blisters, a dry mouth, or dry eyes.

• An incompatibility reaction which may be fatal) in a subject host) of low immunological competence deficient lymphoid tissue) who has been the recipient of immunologically competent lymphoid tissue from a donor who lacks at least one antigen possessed by the recipient host; the reaction, or disease, is the result of action of the transplanted cells against those host tissues that possess the antigen not possessed by the donor. Seen most commonly following bone marrow transplantation, acute disease is seen after 5-40 days and chronic disease weeks to months after transplantation, affecting, principally, the gastrointestinal tract, liver, and skin.

• Caused by immunologically competent t cells in the graft recognizing and attacking host tissues as foreign; clinical symptoms include skin rashes, diarrhea, and abnormal liver functions.

• The clinical entity characterized by anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the graft vs host reaction.

Details

• D89.81 should not be used for reimbursement purposes as there are multiple codes below it that contain a greater level of detail.

• The 2023 edition of ICD-10-CM D89.81 became effective on October 1, 2022.

• This is the American ICD-10-CM version of D89.81 – other international versions of ICD-10 D89.81 may differ.