E16.4

Applicable To

• Hypergastrinemia

• Hyperplasia of pancreatic endocrine cells with gastrin excess

• Zollinger-Ellison syndrome

Approximate Synonyms

• Hypergastrinemia

• Increased gastrin secretion

Clinical Information

• A disorder in which tumors of the pancreatic islet cells produce large amounts of gastrin a hormone), leading to excess acid in the stomach and, possibly, a peptic ulcer ulcer of the stomach or the upper part of the small intestine).

• A syndrome characterized by the presence of a gastrin-secreting tumor, usually in the pancreas or duodenum, resulting in increased gastric acidity and formation of gastric ulcers. Signs and symptoms include abdominal pain and diarrhea. It may be sporadic or a manifestation of multiple endocrine neoplasia type 1.

• A syndrome that is characterized by the triad of severe peptic ulcer, hypersecretion of gastric acid, and gastrin-producing tumors of the pancreas or other tissue gastrinoma). This syndrome may be sporadic or be associated with multiple endocrine neoplasia type 1.

• Triad comprising intractable, sometimes fulminating atypical ulcers, extremely elevated gastic acidity, and gastrin secreting non beta islet cell tumors.

Details

• E16.4 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.

• The 2023 edition of ICD-10-CM E16.4 became effective on October 1, 2022.

• This is the American ICD-10-CM version of E16.4 – other international versions of ICD-10 E16.4 may differ.