E21.0

Applicable To

• Hyperplasia of parathyroid

• Osteitis fibrosa cystica generalisata [von Recklinghausen’s disease of bone]

Approximate Synonyms

• Hyperparathyroidism, primary

• Parathyroid hyperplasia

Clinical Information

• A condition of abnormally elevated output of parathyroid hormone due to parathyroid hyperplasia or parathyroid neoplasms. It is characterized by the combination of hypercalcemia, phosphaturia, elevated renal 1,25-dihydroxyvitamin d3 synthesis, and increased bone resorption.

• Abnormal increase in the number of otherwise normal cells in the parathyroid gland without tumor formation that leading to enlargement of the gland; it differs from hypertrophy, which is an increase in bulk without an increase in the number of cells.

• Hyperfunction of the parathyroid glands resulting in the overproduction of parathyroid hormone. It is caused by parathyroid adenoma, parathyroid hyperplasia, parathyroid carcinoma, and multiple endocrine neoplasia. It is associated with hypercalcemia and hypophosphatemia. Signs and symptoms include weakness, fatigue, nausea, vomiting, constipation, depression, bone pain, osteoporosis, cystic bone lesions, and kidney stones.

Details

• E21.0 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.

• The 2023 edition of ICD-10-CM E21.0 became effective on October 1, 2022.

• This is the American ICD-10-CM version of E21.0 – other international versions of ICD-10 E21.0 may differ.