E31.21

Applicable To

• Wermer’s syndrome

Approximate Synonyms

• Multiple endocrine neoplasia, type 1

• Multiple endocrine neoplasm type 1

Clinical Information

• A form of multiple endocrine neoplasia that is characterized by the combined occurrence of tumors in the parathyroid glands, the pituitary gland, and the pancreatic islets. The resulting clinical signs include hyperparathyroidism; hypercalcemia; hyperprolactinemia; cushing disease; gastrinoma; and zollinger-ellison syndrome. This disease is due to loss-of-function of the men1 gene, a tumor suppressor gene genes, tumor suppressor) on chromosome 11 locus: 11q13).

• A rare, inherited disorder that affects the endocrine glands and can cause tumors in the parathyroid and pituitary glands and the pancreas. These tumors are usually benign not cancer). They cause the glands to secrete high levels of hormones, which can lead to other medical problems, such as kidney stones, fertility problems, and severe ulcers. In some cases, tumors inside the pancreas can become malignant cancer).

• Multiple endocrine neoplasia caused by inactivation of the tumor suppressor gene men-1. Patients may develop hyperparathyroidism and parathyroid gland adenomas, pituitary gland adenomas, pancreatic islet cell neoplasms, and carcinoid tumors.

Details

• E31.21 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.

• The 2023 edition of ICD-10-CM E31.21 became effective on October 1, 2022.

• This is the American ICD-10-CM version of E31.21 – other international versions of ICD-10 E31.21 may differ.