E50.8

Applicable To

• Follicular keratosis

• Xeroderma

Clinical Information

• A non-neoplastic disorder characterized by abnormally dry skin. Causes include vitamin a deficiency, sunlight exposure, medications, metabolic disorders, autoimmune disorders, and hereditary genetic disorders.

• An autosomal dominant inherited chronic skin disorder caused by mutations in the atp2a2 gene. It is characterized by the development of yellow-brown keratotic skin papules in the neck, ears, forehead, chest, back and groin. It is associated with fragility of the free margins of the nails.

• An autosomal dominantly inherited skin disorder characterized by warty malodorous papules that coalesce into plaques. It is caused by mutations in the atp2a2 gene encoding serca2 protein, one of the sarcoplasmic reticulum calcium-transporting atpases. The condition is similar, clinically and histologically, to benign familial pemphigus, another autosomal dominant skin disorder. Both diseases have defective calcium pumps calcium-transporting atpases) and unstable desmosomal adhesion junctions desmosomes) between keratinocytes.

• Slowly progressive autosomal dominant disorder of keratinization with papules on the seborrheic areas of the body that coalesce to form plaques which may become crusted and secondarily infected; lesions may darken and fuse over time to form papillomatous and warty malodorous growths.

Details

• E50.8 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.

• The 2023 edition of ICD-10-CM E50.8 became effective on October 1, 2022.

• This is the American ICD-10-CM version of E50.8 – other international versions of ICD-10 E50.8 may differ.