G10

Huntington’s disease

A familial disorder inherited as an autosomal dominant trait and characterized by the onset of progressive chorea and dementia in the fourth or fifth decade of life. Common initial manifestations include paranoia; poor impulse control; depression; hallucinations; and delusions. Eventually intellectual impairment; loss of fine motor control; athetosis; and diffuse chorea involving axial and limb musculature develops, leading to a vegetative state within 10-15 years of disease onset. The juvenile variant has a more fulminant course including seizures; ataxia; dementia; and chorea. from Adams et al., Principles of Neurology, 6th ed, pp1060-4)

A progressive hereditary neurodegenerative disorder inherited in an autosomal dominant fashion. Symptoms may appear at any age and include uncontrolled movements, clumsiness, balance problems, difficulty walking, talking, or swallowing. The disease has a progressive course with a decline in mental abilities, and the development of psychiatric problems.

Chronic progressive chorea and mental deterioration terminating in dementia; the age of onset usually is in the fourth decade of life.

Huntington’s disease hd) is an inherited disease that causes certain nerve cells in the brain to waste away. People are born with the defective gene, but symptoms usually don’t appear until middle age. Early symptoms of hd may include uncontrolled movements, clumsiness or balance problems. Later, hd can take away the ability to walk, talk or swallow. Some people stop recognizing family members. Others are aware of their environment and are able to express emotions.if one of your parents has huntington’s disease, you have a 50-50 chance of getting it. A blood test can tell if you have the hd gene and will develop the disease. Genetic counseling can help you weigh the risks and benefits of taking the test.there is no cure. Medicines can help manage some of the symptoms, but cannot slow down or stop the disease.

Major neurocognitive disorder in other diseases classified elsewhere unspecified severity, with anxiety